Modeling approach to stimulate the formation of Oxidation LDL after intake of different types of fatty acids
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Date
2019-05-17
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Johns Hopkins University
Abstract
Oxidized lipoprotein (Ox-LDL) has been studied for over 30 years. Multiple lines of evidence have confirmed that oxidation LDL involved in the development of atherosclerosis. Many mechanisms have been proposed for LDL oxidation. However, the physiologically relevant mechanisms of LDL oxidation are still imperfectly understood.
The component of VLDL, mainly consist of cholesterol and triglyceride, sometimes has unsaturated fatty acids tail. We assume that the free radical can react with these unsaturated fatty acids. In this way, the structure of apolipoproteins in LDL will be modified. LDL can be converted to a form that could not be recognized specifically by LDL receptor, but with high affinity to macrophage scavenger receptors, leading to the formation of atherosclerosis.
Based on our assumption, we build a mathematic model to stimulate the process of LDL oxidation. The model demonstrates how different dietary and ratio of unsaturated fatty acids may affect the possibility that LDL convert to oxidation LDL, provide a way to look at LDL oxidation qualitatively and quantitatively.
The goal of this research is to obtain insight into LDL oxidation in the human body and develop strategies to prevent and reduce atherosclerosis.
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Modeling
Oxidation LDL