Simulation of Magnetic Nanoparticle Hyperthermia in Prostate Tumors
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Date
2014-05-09
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Johns Hopkins University
Abstract
In clinical studies, it is difficult to determine the temperature distribution throughout both tumor and normal tissue during hyperthermia treatment, since temperatures are sampled at only a limited number of locations with conventional sensors. Simulation studies can help physicians understand better the effects of the treatment. In this study, three 2D tumor models are built in the COMSOL software environment based on the images of nanoparticle distributions in sliced PC3, DU145 and LAPC4 tumors. The images are pre-processed in MATLAB before being imported into COMSOL. A uniform distribution model is added as a control group. Temperature distribution, maximum temperature, time to reach steady state, CEM43, iso-effective dose and heat flux at tumor-tissue boundary are analyzed to evaluate the effect of the nanoparticle distribution on hyperthermia treatment. The results indicate that a more concentrated nanoparticle distribution is better in damaging diseased tissue than the uniform distribution under low heating power. A more uniform distribution is better than the concentrated distribution under high heating power. For concentrated nanoparticle distributions, the location where the nanoparticles are concentrated influences tissue damage: a more centered one has a better effect.
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Keywords
Magnetic nanoparticle hyperthermia, Simulation, distributions