All-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging
dc.contributor.author | Mavadia, Jessica | |
dc.contributor.author | Xi, Jiefeng | |
dc.contributor.author | Chen, Yongping | |
dc.contributor.author | Xingde, Li1 | |
dc.date.accessioned | 2014-03-28T14:02:03Z | |
dc.date.available | 2014-03-28T14:02:03Z | |
dc.date.issued | 2012-10-12 | |
dc.description | PMC3493218 | en_US |
dc.description.abstract | We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery of OCT source and fluorescence excitation light while collecting the backscattered OCT signal through the single-mode core and fluorescence emission through the large inner cladding of the DCF. Circumferential beam scanning was performed by rotating a 45° reflector using a miniature DC motor at the distal end of the endoscope. Additionally, a custom DCF coupler and a wavelength division multiplexer (WDM) were utilized to seamlessly integrate both imaging modalities to achieve an entirely fiber-optically based dual-modality imaging system. We demonstrated simultaneous intraluminal 3D OCT and 2D (surface) fluorescence imaging in ex vivo rabbit esophagus using the dual-modal endomicroscopy system. Structural morphologies (provided by OCT) and fluorophore distribution (provided by the fluorescence module) could be clearly visualized, suggesting the potential of the dual-modality system for future in vivo and clinical applications. | en_US |
dc.description.sponsorship | JH Libraries Open Access Fund | en_US |
dc.identifier.citation | doi: 10.1364/BOE.3.002851 | en_US |
dc.identifier.issn | 2156-7085 | |
dc.identifier.uri | http://jhir.library.jhu.edu/handle/1774.2/36715 | |
dc.language.iso | en_US | en_US |
dc.publisher | OpticsInfoBase | en_US |
dc.relation.ispartofseries | Biomedical Optics Express;v. 3 no. 11 pp. 2851–2859 2012 | |
dc.subject | Spectroscopy | en_US |
dc.subject | fluorescence and luminescence | en_US |
dc.subject | Endoscopic imaging | en_US |
dc.subject | Optical coherence tomography | en_US |
dc.title | All-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging | en_US |
dc.title.alternative | All fiber optic endoscopy platform for simultaneous OCT and fluorescence imaging | en_US |
dc.type | Article | en_US |
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