A functional cortical network for sensorimotor sequence generation

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dc.contributor.advisorWorley, Paul F
dc.contributor.committeeMemberNielsen, Kristina J
dc.contributor.committeeMemberO'Connor, Daniel H
dc.contributor.committeeMemberBrown, Solange P
dc.contributor.committeeMemberMysore, Shreesh P
dc.creatorXu, Duo
dc.creator.orcid0000-0002-8259-8688
dc.date.accessioned2021-01-08T17:05:26Z
dc.date.available2021-01-08T17:05:26Z
dc.date.created2020-05
dc.date.issued2020-05-12
dc.date.submittedMay 2020
dc.date.updated2021-01-08T17:05:26Z
dc.description.abstractThe brain generates complex sequences of movements that can be flexibly reconfigured in real-time based on sensory feedback, but how this occurs is not fully understood. We developed a novel ‘sequence licking’ task in which mice directed their tongue to a target that moved through a series of locations. Mice could rapidly reconfigure the sequence online based on tactile feedback. Closed-loop optogenetics and electrophysiology revealed that tongue/jaw regions of somatosensory (S1TJ) and motor (M1TJ) cortex encoded and controlled tongue kinematics at the level of individual licks. Tongue premotor (anterolateral motor, ALM) cortex encoded intended tongue angle in a smooth manner that spanned individual licks and even whole sequences, and progress toward the reward that marked successful sequence execution. ALM activity regulated sequence initiation, but multiple cortical areas collectively controlled termination of licking. Our results define a functional cortical network for hierarchical control of sensory- and reward-guided orofacial sequence generation.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/63454
dc.language.isoen_US
dc.publisherJohns Hopkins University
dc.publisher.countryUSA
dc.subjectSensorimotor
dc.subject Sequence
dc.subject Tongue
dc.titleA functional cortical network for sensorimotor sequence generation
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentNeuroscience
thesis.degree.disciplineNeuroscience
thesis.degree.grantorJohns Hopkins University
thesis.degree.grantorSchool of Medicine
thesis.degree.levelDoctoral
thesis.degree.namePh.D.
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