Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis

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dc.contributor.authorArmanios, Mary
dc.contributor.authorQi, Ling
dc.contributor.authorStrong, Margaret A.
dc.contributor.authorKarim, Baktiar O.
dc.contributor.authorGreider, Carol W.
dc.contributor.authorHuso, David L.
dc.date.accessioned2009-11-05T16:46:19Z
dc.date.available2009-11-05T16:46:19Z
dc.date.issued2003-12-01
dc.description.abstractTo examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions compared with either Atm(-/-) or mTR(-/-) iG6 mice. Furthermore, the Atm(-/-) mTR(--) iG6 mice had a delayed onset and reduced incidence of thymic lymphoma compared with Atm(-/-) mice. The tumors in the Atm(-/-) mTR(-/-) iG6 mice showed increased apoptosis and anaphase bridges. Finally, lymphomas from Atm(-/-) mTR(-/-) iG6 mice were derived from CD8 immature, single-positive T cells, whereas Atm(-/-) lymphomas were from CD4(+)CD8(+) double-positive T cells. We propose that Atm protects short telomeres and that Atm deficiency cooperates with short telomeres, leading to increased cell death, decreased tumorigenesis, and increased overall survival.en_US
dc.identifier.citationQi, Ling, et al. "Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis" Cancer Research 63, 8188-8196. December 1, 2003en_US
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/33535
dc.language.isoen_USen_US
dc.publisherAmerican Association of Cancer Researchen_US
dc.subjectTelomere/geneticsen_US
dc.subjectTumor Suppressor Proteinsen_US
dc.subjectCell Transformation, Neoplasticen_US
dc.subjectTelomere/physiologyen_US
dc.subjectTelomerase/deficiencyen_US
dc.titleShort telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesisen_US
dc.typeArticleen_US
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