The Panorama of Cancer Genetics
Embargo until
Date
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
American Association for Cancer Research (AACR)
Abstract
Cancer, a disease of the genome, is caused by a combination of germline predisposing variants and acquired somatic mutations. A unified view of heritable and acquired genetic factors will improve our understanding of cancer occurrence and progression. Fanfani and colleagues provide new insight into heritable cancer risk through a computational method that identifies genes and loci that contribute strongly to cancer heritability; many of these loci also harbor somatic drivers. Beyond improving cancer clinical outcomes, these methods will also be valuable across complex disorders by identifying regions responsible for missing heritability.
Description
Keywords
Citation
Joel S. Bader. (2021-5-14). "The Panorama of Cancer Genetics." Cancer Research. 81 (10). 10.1158/0008-5472.can-21-0885.