COUPLED FLUID-CHEMICAL COMPUTATIONAL MODELING OF ANTICOAGULATION THERAPIES IN A STENTED ARTERY
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Date
2014-05-07
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Johns Hopkins University
Abstract
Stent thrombosis is a major complication that occurs after the placement of stents in the coronary artery through balloon angioplasty, associated with severe medical conditions with a high risk of mortality. The common treatment for stent thrombosis is to provide patients with anticoagulant and antiplatelet therapy through the bloodstream, which has the adverse effect of increased risk of bleeding disorders. This study uses numerical modeling to compare two delivery methods of anticoagulant to the arterial wall to reduce thrombus formation: through the flow and via a drug-eluting stent. A two-dimensional thrombosis model is developed that couples an incompressible flow solver with a convection-diffusion-reaction equation model of the coagulation cascade and platelet activation and aggregation. The results find that the drug-eluting stent delivery of anticoagulant is more effective in reducing platelet activation and clotting, while also providing a more localized anticoagulant distribution.
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Keywords
biomechanics, fluid-structure interaction, stent thrombosis, thrombosis modeling, computational fluid dynamics