Pulmonary Tuberculosis Incidence and Risk Factors in Rural Areas of China: A Cohort Study
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Date
2013-03-12
Authors
Chen, Wei
Shu, Wen
Wang, Min
Hou, Yongchun
Xia, Yinyin
Xu, Weiguo
Bai, Liqiong
Nie, Shaofa
Cheng, Shiming
Xu, Yihua
Journal Title
Journal ISSN
Volume Title
Publisher
PLoS Organization
Abstract
The incidence of tuberculosis (TB) and its risk factors in China remains unclear. This study examined TB incidence and relative risk factors in rural areas of China. Participants (n = 177,529) were recruited in Xiangtan County (in the central area of China) and in Danyang County (in the eastern area of China) in 2009 and a followed-up study was conducted for one year. The incidence density of pulmonary TB and smear-positive TB were 91.6 (95% CI: 78.7, 106.0) per 100,000 person-year and 36.7 (95% CI: 33.1, 52.4) per 100,000 person-year respectively in Xiangtan, and 47.3 (95% CI: 38.2, 57.5) per 100,000 person-year and 22.7 (95% CI: 16.5, 30.8) per 100,000 person-year in Danyang. The medical history of TB was associated with TB, with the relative risk (RR) of 7.00 (95% CI: 2.76, 17.18) in Xiangtan and that of 31.08 (95% CI: 13.22, 73.10) in Danyang. The association between TB and per capita living space over median was found in Xiangtan, with the RR of 1.86 (95% CI: 1.15, 3.01). No association was found between TB and the insurance status, the contact history with TB, the history of diabetes, smoking, or per capita annual income. The host genetic susceptibility, and social factors such as education and income could be considered in future studies.
Description
PMC3595232
Keywords
Tuberculosis, Pulmonary, Rural Population
Citation
doi: 10.1371/journal.pone.0058171