Epidermal stem cells in orthopaedic regenerative medicine.
Embargo until
Date
2013-05-31
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Multidisciplinary Digital Publishing Institute
Abstract
In the last decade, great advances have been made in epidermal stem cell studies at the cellular and molecular level. These studies reported various subpopulations and differentiations existing in the epidermal stem cell. Although controversies and unknown issues remain, epidermal stem cells possess an immune-privileged property in transplantation together with easy accessibility, which is favorable for future clinical application. In this review, we will summarize the biological characteristics of epidermal stem cells, and their potential in orthopedic regenerative medicine. Epidermal stem cells play a critical role via cell replacement, and demonstrate significant translational potential in the treatment of orthopedic injuries and diseases, including treatment for wound healing, peripheral nerve and spinal cord injury, and even muscle and bone remodeling.
Description
PMC3709750
Keywords
Orthopedic Regenerative Medicine, Molecular Biology, Spinal Cord Injury, Peripheral Nerve Injury, Wound Healing, Epidermal Stem Cells
Citation
doi: 10.3390/ijms140611626