Functional characterization and developmental regulation of mouse telomerase RNA
Embargo until
Date
1995-09-01
Journal Title
Journal ISSN
Volume Title
Publisher
American Association for the Advancement of Science
Abstract
Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts. RNA was detected in all newborn mouse tissues tested but was decreased during postnatal development.
Description
Keywords
RNA/metabolism, Gene Expression Regulation, Developmental, DNA Nucleotidylexotransferase /metabolism
Citation
Blasco, Maria A. et al. "Functional characterization and developmental regulation of mouse telomerase RNA" Science 269 (5228) (1995 September 1): 1267-1270. Originally published: DOI: 10.1126/science.7544492