Wild-derived inbred mouse strains have short telomeres
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Date
2000-11-15
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Publisher
Oxford University Press
Abstract
Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.
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Keywords
Telomere/genetics, In Situ Hybridization, Fluorescence, Electrophoresis, Gel, Pulse-Field, DNA/genetics
Citation
Hemann, Michael T. and Carol W. Greider. "Wild-derived inbred mouse strains have short telomeres" Nucleic Acids Research 28 (22) (2000 November 15): 4474-4478. Originally published: http://nar.oxfordjournals.org/cgi/reprint/28/22/4474